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Chromatographic Hydrophobicity Index (CHI):
Application to Agrochemical Research
Eric D. Clarke and Dianne B. Shirley,
Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire
RG42 6EY, United Kingdom.
For ~ five years we have been utilising Klára Valkó’s chromatographic
hydrophobicity index (CHI) to provide an initial assessment of log P octanol and
pKa for exploratory agrochemicals (see Valkó et al, Anal. Chem. (1997) 69,
2022). Work to give indirect determinations of log P octanol and pKa from CHI
values will be outlined and illustrated for a diverse range of agrochemical
products. Data from two exploratory projects will be used to further explore the
application of CHI to basic and acidic compounds. Finally we will discuss a
multi-column/multi-organic solvent gradient matrix approach to determine Abraham
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Physical Chemists by Physical Chemists